Nucleic Acids Chemistry Group

Main research areas

NanoBiotechnology, Nanomedicine, Nanoparticles

Other: Nucleic Acids Chemistry

Main research and technological activities

Expert in oligonucleotide synthesis especially on the methodological aspects of solid-phase synthesis. Experience in most areas related to the synthesis and properties of oligonucleotide derivatives. Research efforts have been concentrated in the following areas: 1) Development of novel RNA derivatives to enhance specific gene silencing properties of siRNA by RNA interference, including nuclease resistant siRNAs, lipid-RNA and development of lipid formulation for siRNA transfection. 2) Modulation of the structural parameters of non-canonical DNA structures such as Gquadruplex, i-motif and parallel duplex by chemical modification. 3) Development of oligonucleotides carrying 8-aminopurines for enhanced binding by triple helix formation. 4) Functionalization of DNA bidimensional arrays and DNA origami. 5) Novel linkers for functionalization of nanomaterials. 6) Synthesis and properties of oligonucleotides carrying non-natural nucleobases for the study of mutagenesis, DNA repair, DNA methylase inhibition. 7) Synthesis of oligonucleotide-peptide conjugates. 8) Development of modified aptamers with enhanced stability in sera.

Available instruments and equipment